Part of US based
Semler Group of Companies,
in business since 1946


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Semler Research Center(SRC) offers a unique combination of highly trained workforce enabled with well-equipped bioanalytical laboratory. We are committed to conducting studies as per sponsor specifications while maintaining highest standards of quality, regulatory requirements and adherence to timelines.

Every study conducted is supervised by a dedicated study director, who monitors all phases of the project, from receipt and inventory of reference materials and samples to preparation of the final report. We ensure that each client has direct access and periodic updates from the scientist/s who are associated with project.

Strict security measures and policies are adopted to ensure that our clients receive services that match the highest levels of compliance without any breach of confidentiality. We have experimental procedures performed in compliance to ICH/FDA guidelines and can be modified to suit user specific requirements.
Key Bioanalytical Services

  • Method development
  • Method validation
  • Method transfer
  • Analysis of clinical study samples by HPLC and LC-MS/MS
  • Analysis of in vitro ADME and in vivo PK/ADME samples by HPLC and LC-MS/MS
  • Analysis of drug and metabolites in different biological fluids by HPLC and LC-MS/MS
  • Analysis of toxico-kinetic study samples by HPLC and LC-MS/M

Pharmacokinetics & Pharmacodynamics

Semler Research Center(SRC) offers pharmacokinetic(PK) and pharmacodynamic(PD) services to ascertain the time course of individual exposure and response to a new treatment regime. Studies are conducted to establish therapeutic schedules, evaluate their relevance, or evaluate dose adjustments in particular patient population. Our capabilities in PK include early exploratory, investigative or screening studies and to support regulatory submissions.

Our Pharmacokineticists, work closely with our statistical, scientific writing and bioanalytical staff at every stage of the study. From initiation to completion and reporting, they ensure a smooth and effective transition of high-quality pharmacokinetic data from our bioanalytical laboratory to the pharmacokinetics department and then to our statistical and medical writing groups. Finally team coordinates in the preparation of comprehensive ICH compliant reports.

PK and PD in Patients

SRC offers a complete range of research services in the areas of pharmacokinetic and ADME studies for small molecules, large molecules, biologics and other related test articles and devices. The studies are conducted to establish therapeutic schedules, to evaluate their relevance or for dose adjustments in particular patients.

Key PK & PD Offerings

  • Input to study design, including pre-clinical to clinical considerations (allometric scaling) utilizing information from pre-clinical toxico-kinetic studies
  • Non-compartmental pharmacokinetics
  • Compartmental pharmacokinetics/simulations
  • Ascending dose (assessment of dose proportionality)
  • Repeat dose (assessment of steady-state kinetics and multiple dose linearity)
  • Bioavailability and bioequivalence
  • Drug interaction studies
  • Special population studies
  • Pharmacodynamic and PK/PD modeling
  • Deconvolution
  • Comprehensive text interpretation of data