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Dr. Suresh Venkataram speaks at Bangalore INDIA BIO organized by Vision Group on Biotechnology

Chief Scientific Officer at SRC, Dr. Suresh Venkataram, speaks on “Challenges and Considerations in Biopharmaceutical Product Development” at the Bangalore INDIA BIO conference organised by 'Vision Group' on Biotechnology between 4th May to 6th May 2011 at Bangalore, India.

 

While most small molecule drugs are chemically stable, large molecules in general and peptides in particular are prone to instability at various stages – manufacturing and storage of drug substance, drug product, reconstituted drug product prior to usage etc. Typical challenges during lyophilisation product development are several – the formulation itself, the primary packaging materials, the process prior to, during, and post-lyophilization. Rational formulation and process design should take in to account phase transition characteristics, pH drifts, concentration gradients that affect primary secondary and tertiary structures of the molecules under development.

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